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Updated: Jan 23, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-light induced decarboxylative alkylation of quinoxalin-2(1H)-ones at the C3-position
Wenxuan Xue1, Yingpeng Su1, Ke-Hu Wang1
1College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, P. R. China. huyl@nwnu.edu.cn.
Abstract:
A simple and efficient method for the visible light induced direct carbon alkylation of quinoxalin-2(1H)-ones at the C3 position is described. This protocol employs cheap and readily available phenyliodine(iii) dicarboxylates as the alkylation reagents to conduct decarboxylative radical coupling reaction with quinoxalin-2(1H)-ones. The process exhibits excellent compatibility to functional groups and provides a convenient and selective access to various 3-alkylquinoxalin-2(1H)-ones in good yields.
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