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Updated: Jan 23, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Multiple sclerosis relapse risk in the postoperative period: Effects of invasive surgery and anesthesia

Lindsey B De Lott1, Samantha Zerafa2, Kerby Shedden3

  • 1Department of Neurology, University of Michigan, Ann Arbor, MI, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|June 26, 2019
PubMed
Abstract

Insights

Surgery does not increase the risk of multiple sclerosis (MS) relapses. This study found no higher odds of postoperative versus preoperative relapse in MS patients undergoing surgery.

Area of Science:

  • Neurology
  • Surgical Outcomes

Background:

  • Postoperative multiple sclerosis (MS) relapses are a significant concern for patients and healthcare providers.
  • Understanding the potential impact of surgery on MS activity is crucial for patient management.

Purpose of the Study:

  • To investigate whether the risk of MS relapse is elevated in the postoperative period.
  • To compare the likelihood of relapse following surgical procedures versus periods preceding surgery within the same patients.

Main Methods:

  • Retrospective analysis of medical records from 281 MS patients who underwent 609 surgeries between 2000 and 2016 at a tertiary care center.
  • Conditional logistic regression was employed to calculate unadjusted and age-adjusted odds ratios for postoperative versus preoperative relapses within individual patients.

Main Results:

  • A total of 12 postoperative relapses were identified among the study cohort.
  • Neither unadjusted (OR=0.56, 95% CI=0.18-1.79) nor age-adjusted (OR=0.66, 95% CI=0.20-2.16) analyses revealed a statistically significant increase in the odds of relapse after surgery compared to before surgery.

Conclusions:

  • Exposure to surgery and anesthesia does not appear to elevate the risk of postoperative relapses in patients with multiple sclerosis.
  • These preliminary findings suggest surgical intervention may be safe concerning MS relapse, but larger studies are warranted for confirmation.
Keywords:
Anesthesialogistic modelsmultiple sclerosispostoperative periodpreoperative periodretrospective studies

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