Chemerin rs17173608 Gene Polymorphism is not Associated with Type 2 Diabetes Mellitus: a Cross-sectional Study

Area of Science:

• Genetics
• Metabolic Diseases
• Molecular Biology

Background:

• Chemerin plays a role in metabolic disorders like obesity, insulin resistance, metabolic syndrome, polycystic ovary syndrome (PCOS), and type 2 diabetes mellitus (T2DM).
• Investigating specific gene polymorphisms, such as Chemerin rs17173608, is crucial for understanding disease mechanisms.

Purpose of the Study:

• To examine the association between the Chemerin rs17173608 gene polymorphism and type 2 diabetes mellitus.
• To determine if this specific polymorphism influences T2DM risk or characteristics.

Main Methods:

• DNA was isolated from 100 T2DM patients and 50 healthy controls.
• Chemerin gene polymorphism (rs17173608) was analyzed using Tetra-Amplification Refractory Mutation System polymerase chain reaction (T-ARMS-PCR).
• Genotyping results were validated using sequence analysis and gel electrophoresis.

Main Results:

• The GG genotype for Chemerin rs17173608 was not detected in either T2DM patients or healthy controls.
• Genotype distribution showed TT and TG genotypes in both groups, with slightly higher TT ratios in T2DM patients.
• No statistically significant differences in genotype or G allele frequency were observed between the T2DM and control groups.

Conclusions:

• This is the first study to investigate the Chemerin rs17173608 gene polymorphism in relation to T2DM.
• Despite observed differences in genotype frequencies, the Chemerin rs17173608 polymorphism does not appear to be significantly associated with T2DM in the studied population.
• Further research with larger cohorts may be warranted to fully elucidate the role of chemerin in T2DM pathogenesis.