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Biomedical applications of radioiodinated peptides

Maria Cristina Oliveira1, João D G Correia1

  • 1Centro de Ciências e Tecnologias Nucleares, Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, CTN, Estrada Nacional 10 (km 139,7), 2695-066, Bobadela LRS, Portugal.

European Journal of Medicinal Chemistry
|June 26, 2019
PubMed

Insights

Radioiodinated peptides are crucial for targeted nuclear imaging and therapy in oncology. This review details radioiodination strategies and their biomedical applications, addressing a gap in current literature.

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiochemistry

Background:

  • Overexpressed peptide receptors in tumors form the basis for targeted molecular imaging and therapy.
  • Radiolabeled peptides are vital tools in nuclear medicine and oncology for imaging and treatment.
  • While various radiolabeled peptides exist, updated reviews on radioiodinated peptides are scarce.

Purpose of the Study:

  • To review synthetic strategies for preparing radioiodinated peptides.
  • To highlight the significance of radioiodine in nuclear medicine.
  • To provide an overview of radioiodination techniques and their biomedical applications.

Main Methods:

  • Literature review of synthetic efforts in radioiodinated peptide preparation.
  • Analysis of radioiodination strategies for biomedical applications.
  • Compilation of relevant examples of radioiodinated peptide use.

Main Results:

  • Established importance of radioiodine in nuclear medicine.
  • Detailed overview of various radioiodination strategies.
  • Presented examples of successful biomedical applications of radioiodinated peptides.

Conclusions:

  • Radioiodinated peptides are essential for targeted nuclear imaging and therapy.
  • This review consolidates key information on their synthesis and application.
  • Further research and application of radioiodinated peptides are encouraged.
Keywords:
Biomedical applicationsMolecular imagingPeptidesRadioiodineRadionuclide therapy

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