Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Design Consideration01:22

Design Consideration

557
Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key...
557
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

281
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
281
Tensile Strength Considerations of Concrete01:16

Tensile Strength Considerations of Concrete

532
Considering the tensile strength of concrete involves recognizing that the theoretical strength of cement paste can be up to a thousand times higher than what is observed in practical applications. This significant discrepancy is largely attributed to the presence of microscopic cracks within the concrete. These cracks tend to amplify stress at their tips when a load is applied, a phenomenon explained by Griffith's theory of brittle fracture.
The dimensions and shape of a concrete specimen...
532
Transmission Line Design Considerations01:23

Transmission Line Design Considerations

606
Aluminum has become the material of choice for overhead transmission lines, surpassing copper due to its abundance and cost-effectiveness. The most prevalent type is the aluminum conductor, steel-reinforced (ACSR), which combines aluminum strands around a steel core. Other variants include all-aluminum conductors (AAC), all-aluminum alloy conductors (AAAC), aluminum conductor alloy-reinforced (ACAR), and aluminum-clad steel conductors. Advanced designs, such as aluminum conductors with steel...
606
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

229
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
229
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

5.4K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variation of caffeine use in late preterm infants in U.S. NICUs over time: A 12-year cohort study.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Rationale and Design of RECOVER-ENERGIZE: A Platform Clinical Trial of Interventions for Exercise Intolerance With and Without Post-exertional Malaise in Long COVID.

medRxiv : the preprint server for health sciences·2026
Same author

Population Pharmacokinetics and Dosing Simulations of Pentobarbital in the Pediatric Population.

Journal of clinical pharmacology·2026
Same author

Conducting multicenter trials through the trial innovation network comprehensive consultation.

Contemporary clinical trials·2026
Same author

Population Pharmacokinetics and Exposure-Safety Analysis of Furosemide in Preterm Infants.

Journal of clinical pharmacology·2026
Same author

Evaluating the duration of post-discontinuation therapeutic ampicillin exposures in preterm infants.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same journal

Regenerative Cell and Cell-Free Therapies for Necrotizing Enterocolitis: Progress Toward Clinical Translation.

American journal of perinatology·2026
Same journal

WIC Participation and the Education-related Gap in Adverse Neonatal Outcomes: A Population-based Cohort Study.

American journal of perinatology·2026
Same journal

Low-Dose Aspirin Prophylaxis for Preeclampsia and the Risk of Postpartum Hypertensive Outcomes: A Propensity Score Analysis.

American journal of perinatology·2026
Same journal

Cystic Periventricular Leukomalacia in Preterm Infants: Clinical Risks, Heart Rate, and Oxygenation Patterns.

American journal of perinatology·2026
Same journal

International Consensus Curriculum and Competency Framework for Maternal Point-of-Care Ultrasound Training.

American journal of perinatology·2026
Same journal

From InSurE to MIST: A Quality Improvement Initiative in a Level IV NICU.

American journal of perinatology·2026
See all related articles

Related Experiment Video

Updated: Jan 23, 2026

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

1.5K

Neonatal Therapeutics: Considerations for Dosing.

Kanecia O Zimmerman1,2, Daniel K Benjamin1,2, Mara L Becker1,2

  • 1Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina.

American Journal of Perinatology
|June 26, 2019
PubMed
Summary
This summary is machine-generated.

Neonates require special drug dosing due to immature physiology. Further research is crucial for safe and effective neonatal therapeutics.

More Related Videos

Primary Dissociated Midbrain Dopamine Cell Cultures from Rodent Neonates
14:13

Primary Dissociated Midbrain Dopamine Cell Cultures from Rodent Neonates

Published on: November 5, 2008

15.3K
Neonatal Subventricular Zone Electroporation
08:06

Neonatal Subventricular Zone Electroporation

Published on: February 11, 2013

13.3K

Related Experiment Videos

Last Updated: Jan 23, 2026

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

1.5K
Primary Dissociated Midbrain Dopamine Cell Cultures from Rodent Neonates
14:13

Primary Dissociated Midbrain Dopamine Cell Cultures from Rodent Neonates

Published on: November 5, 2008

15.3K
Neonatal Subventricular Zone Electroporation
08:06

Neonatal Subventricular Zone Electroporation

Published on: February 11, 2013

13.3K

Area of Science:

  • Neonatal pharmacology and physiology
  • Pediatric drug development

Background:

  • Neonates are a vulnerable population with immature physiology, increasing risks during critical illness.
  • Neonates frequently receive medications lacking sufficient safety, efficacy, and dosing data for this age group.

Purpose of the Study:

  • To highlight the importance of understanding physiological differences in neonates for optimal drug dosing.
  • To emphasize the need for dedicated pharmacokinetic and pharmacodynamic studies in neonates.

Main Methods:

  • Review of physiological differences impacting drug disposition in neonates.
  • Discussion of the necessity for targeted pharmacokinetic (PK) and pharmacodynamic (PD) studies.

Main Results:

  • Physiological immaturity significantly alters drug absorption, distribution, metabolism, and excretion in neonates.
  • Existing drug data is often inadequate for safe and effective neonatal use.

Conclusions:

  • Understanding neonatal physiology is essential for appropriate therapeutic agent dosing.
  • Well-designed PK/PD studies are critical for developing safe and effective neonatal therapeutics.