Related Experiment Video

Updated: Jan 23, 2026

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

3.1K

Coronary microvascular dysfunction: a key step in the development of uraemic cardiomyopathy?

Ashwin Radhakrishnan1,2, Luke C Pickup1,2, Anna M Price1,3

  • 1Birmingham Cardio-Renal Group, Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.

Heart (British Cardiac Society)
|June 27, 2019
PubMed

Insights

Uraemic cardiomyopathy, common in chronic kidney disease, involves heart muscle changes and increases cardiovascular risk. Coronary microvascular dysfunction may be a key factor driving its development.

Area of Science:

  • Cardiology
  • Nephrology
  • Cardiovascular Medicine

Background:

  • Uraemic cardiomyopathy (UCM) is prevalent in chronic kidney disease (CKD).
  • UCM presents as left ventricular hypertrophy, fibrosis, and impaired systolic/diastolic function.
  • It significantly elevates cardiovascular morbidity and mortality risk in CKD patients.

Purpose of the Study:

  • To review the current understanding of UCM pathophysiology.
  • To explore the potential role of coronary microvascular dysfunction (CMD) in UCM.
  • To evaluate methods for assessing coronary microvascular function and evidence for CMD in CKD.

Main Methods:

  • Literature review of UCM and CMD.
  • Analysis of pathophysiological mechanisms linking CKD and cardiac dysfunction.
  • Evaluation of diagnostic techniques for coronary microvascular function.

Main Results:

  • The exact mechanisms of UCM remain incompletely understood.
  • CMD is a shared feature in phenotypically similar myocardial diseases (e.g., hypertrophic cardiomyopathy, HFpEF).
  • Growing evidence suggests CMD is a significant factor in CKD-related cardiac pathology.

Conclusions:

  • Coronary microvascular dysfunction is proposed as a key mediator in UCM development.
  • Further research is needed to elucidate the precise role of CMD in CKD.
  • Understanding CMD mechanisms may offer new therapeutic targets for UCM.

Keywords:
myocardial disease

More Related Videos

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

2.0K
Measurement of Myocardial Lactate Production for Diagnosis of Coronary Microvascular Spasm06:18

Measurement of Myocardial Lactate Production for Diagnosis of Coronary Microvascular Spasm

Published on: September 17, 2021

1.8K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
492
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
488
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
433
Key Techniques in Microbiology01:19

Key Techniques in Microbiology

Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
1.8K
Key Elements for Plant Nutrition02:35

Key Elements for Plant Nutrition

Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.0K
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
521