Conformational changes influence clogging behavior of micrometer-sized microgels in idealized multiple constrictions

Area of Science:

• Fluid dynamics
• Materials science
• Biophysics

Background:

• Understanding soft particle clogging in porous media is crucial for optimizing processes like membrane filtration.
• Microfluidic devices enable in situ observation of pore clogging mechanisms using high-speed cameras.

Purpose of the Study:

• To investigate the clogging behavior of micrometer-sized microgels in microfluidic devices.
• To quantify clog propensity, clogging position, and particle deformation in relation to particle size and constriction geometry.

Main Methods:

• Utilized microfluidic devices with parallel channels to simulate porous media.
• Observed and quantified the clogging of microgels (larger than pores) using high-speed cameras.
• Analyzed microgel deformation and volume changes (2D projection) based on particle size and constriction entrance angle.

Main Results:

• The majority of microgels clogged at the first constriction, irrespective of particle size and constriction entrance angle.
• Microgel deformation increased with particle size and was dependent on the constriction entrance angle.
• Microgel volume changes were not dependent on the constriction entrance angle.

Conclusions:

• The initial constriction is the primary site for microgel clogging in this porous media model.
• Particle size and constriction geometry significantly influence microgel deformation during clogging.
• Microgel volume remains relatively stable during the clogging process, independent of constriction geometry.