Circular RNAs in hypertension: challenges and clinical promise

Area of Science:

• Biochemistry
• Genetics
• Cardiovascular Medicine

Background:

• Hypertension (high blood pressure) is a major global health issue, contributing significantly to cardiovascular morbidity and mortality.
• Current diagnostic biomarkers for hypertension explain limited phenotypic variance, necessitating the search for novel predictive markers.
• Circular RNAs (circRNAs) are regulatory molecules involved in various diseases, including metabolic disorders.

Purpose of the Study:

• To review current research on the role of circRNAs in hypertension pathogenesis.
• To highlight challenges and future perspectives in circRNA research for hypertension.

Main Methods:

• Literature review of studies investigating circRNAs in hypertension.
• Analysis of circRNA expression patterns and their association with hypertension development.
• Examination of circRNAs as potential biomarkers and therapeutic targets.

Main Results:

• Aberrant expression of circRNAs is implicated in the development and progression of hypertension.
• CircRNAs are emerging as promising novel biomarkers for early hypertension prediction and diagnosis.
• These regulatory RNAs show potential as therapeutic targets for various forms of hypertension.

Conclusions:

• CircRNAs represent a new generation of biomarkers for hypertension, offering improved diagnostic accuracy.
• Targeting circRNAs may provide novel therapeutic strategies for managing hypertension and related cardiovascular conditions.
• Further research is needed to overcome challenges and fully elucidate the role of circRNAs in hypertension.