Endorphins contribute to the loss of glucose homeostasis in anaphylactic shock

Central injection of naloxone attenuated the development of hyperglycemia following induction of non-fatal anaphylaxis in mice, but it failed to reverse the hyperglycemia in this model. In contrast, central TRH both blocked as well as reversed the hyperglycemic response. These results suggest a possible role for central endorphin mechanisms in the hyperglycemic response to anaphylactic shock in mice. Further, they demonstrate a novel action of TRH to block shock-induced hyperglycemia. This antihyperglycemic action of TRH is independent of opiate mechanisms.