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Effects of morphine and calcium antagonists on plasma glucose in male rats
M Szikszay1, F R Snyder, E D London
1Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, Maryland 21224.
NIDA Research Monograph
|January 1, 1986
Abstract:
Subcutaneous administration of morphine sulfate (4-16 mg/kg) did not significantly alter the plasma glucose concentration in fasted adult male Fischer-344 rats. All rats treated with calcium channel antagonists, verapamil or diltiazem (10 mg/kg, with or without morphine), showed marked and significant hyperglycemia, persisting at high levels throughout the 2 h experiment.