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Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord
M C Fournié-Zaluski1, S Bourgoin, F Cesselin
1Chimie Organique, U 266 INSERM, UA 498 CNRS, Faculté de Pharmacie, Paris, France.
Abstract:
Kelatorphan, a mixed inhibitor of "enkephalinases" is used for demonstrating the implication of endogenous enkephalins in nociceptive transmission at the spinal level.