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Morphine metabolism in mouse brain
A Wahlström1, L Hammar, L G Lundin
1Div. of Clinical Pharmacology, University Hospital, Uppsala, Sweden.
Abstract:
Morphine UDP-glucuronyltransferase activity was demonstrated in the brain of mice from recombinant inbred strains of the BXD series. The formation rate of morphine-3-glucuronide was about 4 fold higher in the progenitor DBA as compared to the C57BL strain.