Primary Cardiac Tumors in Infancy: A Case Report and Literature Review
Carolina Dominguez1, Ashley Perkins1, Alexandra Duque2
1University of South Florida - Pathology and Cell Biology.
Insights
Sudden infant death from primary cardiac tumors is rare. A case report details an 8-month-old infant whose death was caused by a left ventricular fibroma, leading to cardiogenic shock.
Area of Science:
- Pediatric Pathology
- Cardiovascular Medicine
- Forensic Science
Background:
- Sudden death in infants is uncommon, with primary cardiac tumors being an exceedingly rare cause.
- This case involves an 8-month-old male infant presenting with sudden cyanosis and loss of consciousness after feeding.
Purpose of the Study:
- To report a rare case of sudden infant death attributed to a primary cardiac tumor.
- To elucidate the cause, manner, and mechanism of death through forensic autopsy and histological examination.
Main Methods:
- Forensic autopsy of an 8-month-old infant with a history of sudden collapse.
- Histological examination of a cardiac mass identified during autopsy.
- Clinical correlation of autopsy findings with reported events.
Main Results:
- Autopsy revealed a eutrophic infant with cyanosis and no signs of external trauma.
- A single, white, whorled cardiac tumor was found in the anterior wall of the left ventricle.
- Histological diagnosis confirmed the tumor as a fibroma.
Conclusions:
- The infant's death was attributed to cardiogenic shock resulting from a primary cardiac fibroma.
- This case highlights the potential for cardiac fibromas to cause sudden, fatal events in infants.
- Emphasizes the importance of considering cardiac pathology in unexplained sudden infant deaths.
Abstract:
Sudden death in infants due to primary cardiac tumors is extremely rare. Herein we describe a case of an 8-month-old male infant, without any previous medical history, who died in a hospital in the city of Medellín-Antioquia, Colombia. The family stated that approximately 15 minutes after he received a bottle, the baby became cyanotic and subsequently lost consciousness. He was taken to the hospital immediately; however, he arrived lifeless. As this was a sudden death case, the child was referred to the Institute of Legal Medicine and Forensic Sciences in the city of Medellín to clarify the cause, manner, and mechanism of death. The forensic autopsy revealed a eutrophic infant with central and peripheral cyanosis, without signs of trauma, and the internal examination found a single cardiac tumor in the anterior wall of the left ventricle. The mass was white and whorled; histological evaluation diagnosed a fibroma. The manner of death was natural due to a cardiogenic shock caused by a primary tumor.
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