Related Experiment Video

Updated: Jan 23, 2026

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
09:06

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Published on: November 11, 2021

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A Pediatric Case of Diffuse Glioma Diagnosed at Autopsy

Jennifer Ross1, Adriana Olar2, Christine Fuller3

  • 1Harris County Institute of Forensic Sciences - Pathology.

Academic Forensic Pathology
|June 27, 2019
PubMed

Insights

Sudden death in children due to undiagnosed brain tumors is rare. This case report details a pediatric glioma with gliomatosis cerebri (GC) infiltration, examining its characteristics and comparing them to existing knowledge on pediatric diffuse gliomas.

Area of Science:

  • Neuro-oncology
  • Pediatric Pathology
  • Neuropathology

Background:

  • Sudden death from primary intracranial neoplasms is rare in pediatrics.
  • Gliomatosis cerebri (GC) is a diffuse glioma infiltration pattern typically seen in adults.
  • Pediatric diffuse gliomas with widespread brain invasion are infrequently documented.

Purpose of the Study:

  • To report a rare case of pediatric glioma exhibiting a gliomatosis cerebri pattern.
  • To analyze the immunohistochemical and molecular features of this pediatric GC.
  • To compare findings with existing literature on pediatric diffuse gliomas.

Main Methods:

  • Autopsy-based diagnosis of a pediatric glioma with GC infiltration.
  • Immunohistochemical analysis of tumor markers.
  • Molecular characterization of the tumor.
  • Literature review and comparison with pediatric diffuse glioma data.

Main Results:

  • Confirmed a rare pediatric glioma with extensive GC infiltration.
  • Detailed immunohistochemical profile of the tumor.
  • Molecular data provided insights into its characteristics.
  • Comparison highlighted similarities and differences with adult GC and other pediatric gliomas.

Conclusions:

  • Pediatric gliomas can rarely present with a gliomatosis cerebri pattern.
  • This case expands understanding of rare pediatric brain tumors.
  • Further research is needed on pediatric diffuse gliomas with widespread invasion.

Keywords:
AutopsyDiffuse gliomaForensic pathologyGliomatosis cerebriInfiltrating astrocytomaPediatric brain tumor

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