Use of the Recombinant Tissue Plasminogen Activator in the Management of Complex Infected Intraperitoneal Fluid...

Area of Science:

• Infectious Diseases
• Interventional Radiology
• Gastroenterology

Background:

• Intra-abdominal infections and infected fluid collections stem from local infections, frequently involving the gastrointestinal or genitourinary tracts.
• These infections are typically polymicrobial, necessitating comprehensive management strategies.

Observation:

• Effective management hinges on source control and judicious antimicrobial therapy.
• Source control can be achieved through surgical intervention or percutaneous drainage of fluid collections.

Findings:

• Interventional radiology drainage presents a crucial alternative for patients with high surgical risk or those declining surgery.
• This case demonstrates the successful application of recombinant intraperitoneal tissue plasminogen activator in managing a complex, polymicrobial intra-abdominal fluid collection.

Implications:

• Recombinant intraperitoneal tissue plasminogen activator offers a promising, less invasive approach for selected patients with complex intra-abdominal infections.
• This case underscores the expanding role of interventional radiology in treating challenging intra-abdominal pathologies.