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Updated: Sep 27, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
2,2':6',2''-Terpyridine switches from tridentate to monodentate coordination in a gold(iii) terpy complex upon
Kun Peng1, Alexandra Friedrich1, Ulrich Schatzschneider1
1Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany. ulrich.schatzschneider@uni-wuerzburg.de.
Abstract:
Reaction of [AuCl(terpy-κ3-N1,1',1'')]Cl2 with an excess of sodium azide did not result in the expected exchange of the chlorido by an azido ligand to give [Au(N3)(terpy-κ3-N1,1',1'')]2+. Instead, X-ray structure analysis showed that the isolated product is [Au(N3)3(terpy-κ1-N1)], in which the terpyridine ligand is in a very rare monodentate coordination mode. This is also the dominant species in solution, together with a minor amount of [Au(N3)2(terpy-κ2-N1,1')]+. The stability of the tris(azido)gold(iii) moiety relative to other possible species was also confirmed by DFT calculations.
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