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Biomarkers for PTLD diagnosis and therapies

Olivia M Martinez1,2

  • 1Department of Surgery/Division of Abdominal Transplantation, Stanford, CA, USA. omm@stanford.edu.

Pediatric Nephrology (Berlin, Germany)
|June 27, 2019
PubMed

Insights

Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after pediatric transplantation, often linked to Epstein-Barr virus (EBV). Identifying biomarkers is crucial for personalized diagnosis and treatment of EBV+ PTLD.

Area of Science:

  • Pediatric Transplantation
  • Immunology
  • Oncology

Background:

  • Post-transplant lymphoproliferative disorder (PTLD) is a significant complication following pediatric transplantation.
  • The majority of PTLD cases are associated with Epstein-Barr virus (EBV), leading to EBV+ B cell lymphomas, the primary post-transplant malignancy in children.
  • EBV+ PTLD is attributed to impaired immunity against EBV due to immunosuppression, but the precise viral and immune factors remain unclear.

Purpose of the Study:

  • To review current biomarker candidates for EBV+ PTLD.
  • To explore immune-, viral-, and B cell lymphoma-derived factors as potential biomarkers.
  • To highlight the need for personalized approaches in diagnosing and managing EBV+ PTLD.

Main Methods:

  • Literature review of immune-, viral-, and B cell lymphoma-derived biomarkers.
  • Analysis of current research on EBV+ PTLD pathogenesis.
  • Synthesis of information regarding diagnostic and therapeutic strategies.

Main Results:

  • EBV+ PTLD is a major challenge in pediatric transplantation, driven by impaired EBV immunity.
  • Several candidate biomarkers from immune, viral, and B cell lymphoma sources are under investigation.
  • The development of personalized diagnostic and treatment strategies is a key focus.

Conclusions:

  • Biomarkers are essential for improving the clinical diagnosis, management, and treatment of EBV+ PTLD in pediatric transplant recipients.
  • Further research into viral, immune, and lymphoma-derived factors is needed to identify reliable biomarkers.
  • Personalized medicine approaches hold promise for addressing the complexities of EBV+ PTLD.

Keywords:
BiomarkerEBVPTLD

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