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Related Concept Videos

The Uncertainty Principle04:08

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Werner Heisenberg considered the limits of how accurately one can measure properties of an electron or other microscopic particles. He determined that there is a fundamental limit to how accurately one can measure both a particle’s position and its momentum simultaneously. The more accurate the measurement of the momentum of a particle is known, the less accurate the position at that time is known and vice versa. This is what is now called the Heisenberg uncertainty principle. He...
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The Pauli Exclusion Principle03:06

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The Aufbau Principle and Hund's Rule03:02

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To determine the electron configuration for any particular atom, we can build the structures in the order of atomic numbers. Beginning with hydrogen, and continuing across the periods of the periodic table, we add one proton at a time to the nucleus and one electron to the proper subshell until we have described the electron configurations of all the elements. This procedure is called the aufbau principle, from the German word aufbau (“to build up”). Each added electron occupies the...
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Le Chatelier's Principle: Changing Concentration02:27

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Archimedes' Principle01:13

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Archimedes' principle states that an upward buoyant force exerted on a body that is immersed partially or entirely in a fluid is equal to the weight of the fluid displaced by it. To understand how much buoyant force is needed to make an object float, let us think about what happens when a submerged object is removed from a fluid. If the object were not in the fluid, the space occupied by the object would be filled by the fluid having a weight wfl. This weight is supported by the...
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Principles of Rodent Surgery for the New Surgeon
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[Principles of sarcoma surgery].

J Jakob1, P Hohenberger2

  • 1Klinik für Allgemein‑, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland. Jens.Jakob@med.uni-goettingen.de.

Der Pathologe
|June 27, 2019
PubMed
Summary
This summary is machine-generated.

This review covers surgical strategies for soft-tissue sarcomas, focusing on diagnostics and multimodal therapy. Advances minimize disfigurement in extremity sarcomas but emphasize multivisceral resection for retroperitoneal types.

Keywords:
Combined modality therapyCore needle biopsyExtremitiesReconstructive surgical proceduresSarcoma

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Cancer Research

Background:

  • Soft-tissue sarcomas are rare malignant neoplasms.
  • Surgery is the primary treatment for soft-tissue sarcomas.
  • Multimodal therapies (chemotherapy, radiotherapy) are used adjunctively.

Purpose of the Study:

  • To review diagnostic approaches for soft-tissue sarcomas.
  • To discuss multimodal therapeutic strategies.
  • To outline surgical resection strategies.

Main Methods:

  • Review of current literature on sarcoma diagnostics.
  • Analysis of neoadjuvant and adjuvant treatment protocols.
  • Evaluation of surgical techniques for extremity and retroperitoneal sarcomas.

Main Results:

  • Surgical advancements have reduced the need for disfiguring surgeries in extremity sarcomas.
  • Multivisceral resection is standard for retroperitoneal sarcomas due to high recurrence rates.
  • Multimodal therapy improves local and systemic outcomes.

Conclusions:

  • Surgical expertise is crucial for managing soft-tissue sarcomas.
  • Tailored resection strategies are essential based on sarcoma location.
  • Integrated multimodal treatment optimizes patient outcomes.