Related Experiment Video

Updated: Jan 23, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.6K

Prevalence and prognostic impact of left ventricular non-compaction in patients with thalassemia

Rodolfo Bonamini1, Massimo Imazio2, Riccardo Faletti1

  • 1Department of Surgical Sciences, Radiology Unit, University of Torino, Turin, Italy.

Internal and Emergency Medicine
|June 27, 2019
PubMed

Insights

Left ventricular non-compaction (LVNC) is common in thalassemia patients but does not worsen heart function or lead to adverse events over time. This finding suggests LVNC in thalassemia may not require specific clinical intervention.

Area of Science:

  • Cardiology
  • Hematology
  • Medical Imaging

Background:

  • Previous studies reported high incidence of left ventricular non-compaction (LVNC) in thalassemia patients using cardiac MRI.
  • The clinical impact of LVNC in this population remains largely unknown.

Purpose of the Study:

  • To prospectively evaluate the prevalence and clinical implications of LVNC in patients with thalassemia.
  • To assess the long-term impact of LVNC on cardiac function and clinical outcomes.

Main Methods:

  • Prospective cohort study including 560 thalassemia patients undergoing cardiac MRI.
  • LVNC diagnosis based on Petersen and Jacquier methods with proposed modifications.
  • Clinical follow-up for a mean of 5.1 years.

Main Results:

  • LVNC was diagnosed in 7.9% of patients (44/560).
  • Patients with LVNC showed significantly lower ejection fraction and greater indexed LV ESV.
  • No significant changes in MRI parameters or adverse clinical events were observed during follow-up.

Conclusions:

  • LVNC is a relatively frequent finding in patients with thalassemia.
  • Despite initial differences in cardiac function, LVNC is not associated with worsening LV function or adverse events in the long-term follow-up.

Keywords:
Cardiac magnetic resonanceLeft ventricular non-compactionPrognosisThalassemia

More Related Videos

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

24.7K
Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

20.1K

Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.6K
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.2K
Compacting Factor test01:22

Compacting Factor test

The compacting factor test is a method used to assess the workability of concrete. It is  especially suitable for concrete mixes containing aggregates up to one and a half inches in size. This test involves specialized equipment consisting of two truncated cone-shaped hoppers and a cylinder, all with polished interior surfaces to minimize friction.
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...
561
Impact of Groups on Groups01:19

Impact of Groups on Groups

Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
236
Impact01:30

Impact

Impact occurs when two bodies collide, leading to the application of impulsive forces between them. Analyzing impact mechanics involves considering two colliding particles moving along a line known as the line of impact, which passes through their centers and is perpendicular to the contact plane.
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
483
Impact Loading01:19

Impact Loading

Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...
670