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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
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Non-coding RNA involvement in the pathogenesis of diabetic cardiomyopathy
Wei Zhang1, Weiting Xu1, Yu Feng2
1Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Journal of Cellular and Molecular Medicine
|June 27, 2019
Summary
Diabetes is rising, leading to diabetic cardiomyopathy. This review explores how non-coding RNAs (ncRNAs) like microRNAs, long ncRNAs, and circular RNAs contribute to this heart condition, offering insights into cardiovascular complications.
Area of Science:
- Cardiology
- Genetics
- Molecular Biology
Background:
- Diabetes mellitus incidence is rapidly increasing globally.
- Diabetic cardiomyopathy is a major cardiovascular complication characterized by fibrosis, remodeling, and dysfunction.
- Pathogenesis involves mitochondrial dysfunction, oxidative stress, inflammation, autophagy, apoptosis, microangiopathy, and fibrosis.
Purpose of the Study:
- To review the pathological roles of non-coding RNAs (ncRNAs) in diabetic cardiomyopathy.
- To elucidate the involvement of microRNAs, long ncRNAs, and circular RNAs in disease progression.
- To provide insights into the molecular mechanisms of diabetic cardiovascular complications.
Main Methods:
- Literature review of studies on non-coding RNAs and diabetic cardiomyopathy.
- Analysis of molecular biology research detailing ncRNA functions.
- Synthesis of evidence on ncRNAs' roles in myocardial fibrosis and cardiac dysfunction.
Main Results:
- Non-coding RNAs (ncRNAs) are critically involved in the molecular mechanisms of diabetic cardiomyopathy.
- MicroRNAs, long ncRNAs, and circular RNAs play significant pathological roles.
- Accumulating evidence highlights ncRNAs' contribution to disease progression.
Conclusions:
- Non-coding RNAs are key players in the pathogenesis of diabetic cardiomyopathy.
- Understanding ncRNA roles may offer novel therapeutic targets for diabetic cardiovascular complications.
- This review consolidates current knowledge on ncRNAs in diabetic heart disease.
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