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Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis
Meiyue Song1, Na Li2, Yan Yao3
1Beijing University of Chinese Medicine and China-Japan Friendship Hospital, Beijing, China.
Journal of Cellular and Molecular Medicine
|June 27, 2019
Summary
High serum uric acid (SUA) levels are linked to a greater risk of multiterritorial vascular stenosis. This prospective cohort study found hyperuricaemia significantly increases the likelihood of developing vascular disease.
Area of Science:
- Cardiovascular Medicine
- Vascular Biology
- Metabolic Syndrome
Background:
- Multiterritorial atherosclerosis significantly elevates the risk of adverse cardiovascular events compared to single-artery disease.
- Serum uric acid (SUA) is recognized as a predictor of stroke and atherosclerosis, yet direct evidence from cohort studies remains limited.
Purpose of the Study:
- To investigate the association between serum uric acid levels and multiterritorial vascular stenosis in North Chinese adults.
- To determine if hyperuricaemia is an independent risk factor for new-onset vascular stenosis.
Main Methods:
- A prospective cohort study involving 2644 North Chinese adults aged ≥40 years (2010-2012).
- Vascular stenosis assessed using transcranial Doppler (TCD) and bilateral carotid duplex ultrasound for intracranial (ICAS) and extracranial (ECAS) arteries.
- Peripheral arterial disease (PAD) determined by ankle-brachial index (ABI).
- Hyperuricaemia defined as SUA >6 mg/dL (males) and >7 mg/dL (females).
Main Results:
- The cumulative incidence of vascular stenosis was significantly higher in subjects with hyperuricaemia (54.1%) than in those without (34.7%, P < 0.001).
- Adjusted odds ratios (ORs) indicated that hyperuricaemia increased the risk of new-onset vascular stenosis by 1.75 times (95% CI: 1.32-2.31).
- A 1-mg/dL increase in SUA was associated with a 1.29 times higher risk (95% CI: 1.21-1.38).
- Gender-stratified analysis showed a significant association between SUA and ICAS in males (OR: 2.02), but not in females (OR: 0.85, P for interaction: 0.026).
Conclusions:
- Elevated serum uric acid levels, indicative of hyperuricaemia, are significantly associated with an increased risk of multiterritorial vascular stenosis.
- The findings suggest SUA is a valuable predictor for vascular stenosis, particularly intracranial artery stenosis in males.
- Further research is warranted to explore the mechanisms and gender-specific implications of SUA in vascular disease progression.
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