Circular RNAs as novel regulators, biomarkers and potential therapies in fibrosis

Fibrosis is the excess deposition of extracellular matrix components which ultimately leads to the disruption of organ architecture and loss of function. Circular RNAs (circRNAs) are a newly discovered type of long noncoding RNAs with single-stranded covalently closed loops. It is known that circRNAs are novel regulators of gene expression via various ways, including miRNA sponge, protein sponge, regulation of transcription and post transcription. Recently, a growing body of evidence suggests that circular RNAs are also involved in tissue fibrosis in several organs. In this review, we summarized current studies of circular RNAs in fibrosis and hopefully aid in better understanding the molecular mechanism of fibrosis and provide a basis to explore new therapeutic targets of fibrosis.