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Updated: Jan 23, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Osimertinib-induced severe interstitial lung disease: A case report
Mengdi Fan1, Ting Mo2, Lulei Shen2
1Department of Endocrinology, Shu Lan (HangZhou) Hospital, Hangzhou, China.
Abstract:
Lung cancer is globally one of the leading causes of malignant tumor-related mortality and ranks as having the highest incidence found in men and second in women. Osimertinib is a drug used to target lung cancer but its toxicity is not fully understood. Here we present a case of lung adenocarcinoma in a 78-year-old man that was treated and responded favorably with Osimertinib after the failure of other therapies. Unfortunately, the patient developed severe interstitial lung disease during the treatment procedure.
Insights
Osimertinib effectively treated lung adenocarcinoma in a patient who failed other therapies. However, this targeted therapy also caused severe interstitial lung disease, highlighting its potential toxicity.
Area of Science:
- Oncology
- Pulmonology
- Pharmacology
Background:
- Lung cancer remains a leading cause of cancer mortality worldwide.
- Osimertinib is a targeted therapy for lung cancer, but its adverse effects require further investigation.
- Interstitial lung disease is a serious potential complication of cancer treatments.
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