PREVALENCE OF HEPATIC STEATOSIS AMONG CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS AND ITS ASSOCIATION WITH
Amanda Oliva Gobato1, Ana Carolina Junqueira Vasques1, Antonio Fernando Ribeiro1
1Universidade Estadual de Campinas, Campinas, SP, Brazil.
Summary
The study found a high prevalence of hepatic steatosis (HS) in children with cystic fibrosis (CF). Nutritional status, assessed by BMI and skinfold thickness, was not linked to HS, but muscle mass indicators were higher in those with HS.
Area of Science:
- Pediatrics
- Gastroenterology
- Pulmonology
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs.
- Hepatic steatosis (HS), or fatty liver disease, is a potential complication in CF patients.
- Understanding the relationship between HS and nutritional status in CF is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of hepatic steatosis (HS) in pediatric and adolescent patients diagnosed with cystic fibrosis (CF).
- To investigate the association between HS and various nutritional status indicators in this population.
Main Methods:
- A cross-sectional study involving children and adolescents with a confirmed CF diagnosis.
- Nutritional status assessed using Body Mass Index (BMI), midarm circumference (MAC), triceps skinfold thickness (TSF), and midarm muscle circumference (MAMC).
- Hepatic steatosis diagnosed via abdominal ultrasonography; statistical analyses included Student's t test, Mann-Whitney test, and chi-square test.
Main Results:
- Out of 50 CF patients, 18 (36%) were diagnosed with HS.
- No significant differences in age, BMI, or TSF were observed between patients with and without HS.
- Patients with HS showed significantly higher MAC and MAMC, suggesting greater muscle mass reserves (p=0.047 and p=0.043, respectively).
Conclusions:
- Hepatic steatosis occurs frequently in children and adolescents with cystic fibrosis.
- HS in this cohort is not associated with malnutrition based on BMI, TSF, and MAMC parameters.
- Elevated MAC and MAMC in HS patients indicate a potential link to increased muscle mass rather than malnutrition.
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