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Dopaminergic D-1 receptors: essential role in morphine-induced hypermotility
R Longoni1, L Spina, G Di Chiara
1Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Italy.
Psychopharmacology
|January 1, 1987
Abstract:
Administration of morphine HCl (20 mg/kg SC) to male C57Bl/6 mice evoked hypermotility. Pretreatment with low doses of the specific D-1 antagonist SCH 23390 (0.006, 0.012, 0.025 mg/kg SC) dose-dependently inhibited morphine-evoked hypermotility. The results suggest that dopamine is the essential mediator of opiate hypermotility and indicate that D-1 receptors play an important role in this effect.