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Related Concept Videos

Transcription Factors02:16

Transcription Factors

82.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.3K
Transcription Elongation Factors02:35

Transcription Elongation Factors

13.5K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
13.5K
Transcription Elongation Factors02:35

Transcription Elongation Factors

4.6K
4.6K
General Transcription Factors01:30

General Transcription Factors

6.8K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
6.8K
Transcription01:10

Transcription

155.7K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
155.7K
Master Transcription Regulators02:23

Master Transcription Regulators

7.7K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.7K

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Updated: Jan 23, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

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The transcription factor MITF in RPE function and dysfunction.

Xiaoyin Ma1, Huirong Li1, Yu Chen1

  • 1Laboratory of Developmental Cell Biology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, and State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou, 325003, China.

Progress in Retinal and Eye Research
|June 27, 2019
PubMed
Summary
This summary is machine-generated.

The microphthalmia-associated transcription factor (MITF) is crucial for retinal pigment epithelium (RPE) development and function. MITF deficiencies are linked to retinal degeneration and impact RPE cell physiology, highlighting challenges in neuroprotection.

Keywords:
MelanocyteMicrophthalmiaRetinal degenerationRetinal pigment epithelium

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Area of Science:

  • Ophthalmology
  • Genetics
  • Cell Biology

Background:

  • Retinal pigment epithelium (RPE) dysfunction is central to mammalian retinal degenerative diseases.
  • The microphthalmia-associated transcription factor (MITF) is essential for RPE development and function.
  • MITF germline mutations cause albinism, microphthalmia, retinal degeneration, and melanoma risk.

Purpose of the Study:

  • To review the multifaceted roles of MITF in RPE biology.
  • To discuss MITF's involvement in RPE development, homeostasis, and degeneration.
  • To identify challenges and future directions for neuroprotective strategies in MITF-related retinal disorders.

Main Methods:

  • Literature review of studies on MITF and RPE.
  • Analysis of MITF's functions including melanogenesis, trophic factor regulation, proliferation, antioxidant activity, and the visual cycle.
  • Discussion of clinical implications and therapeutic strategies.

Main Results:

  • MITF plays critical roles in RPE cell physiology and development.
  • MITF deficiency is associated with various retinal degenerative conditions.
  • Understanding MITF's functions is key to developing effective treatments.

Conclusions:

  • MITF is a key regulator of RPE health and function.
  • Deficiencies in MITF or its target genes contribute to retinal degeneration.
  • Further research into MITF-dependent pathways is crucial for novel neuroprotective therapies.