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Drug and vaccine development.

A Davis1

  • 1Parasitic Diseases Programme, World Health Organization, Geneva, Switzerland.

Tropical Medicine and Parasitology : Official Organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft Fur Technische Zusammenarbeit (GTZ)
|September 1, 1987
PubMed
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The World Health Organization (WHO) funds and coordinates research in communicable diseases and vaccine development. Key areas include malaria vaccines, leishmaniasis treatments, and parasitic infection control programs.

Area of Science:

  • Global Health
  • Infectious Diseases
  • Medical Research

Background:

  • The World Health Organization (WHO) actively engages in research and development for communicable diseases and vaccines.
  • WHO's research interests encompass a broad spectrum of infectious agents and applied vaccinology.
  • This review highlights WHO's role in initiating, coordinating, and funding critical health initiatives.

Purpose of the Study:

  • To review WHO's contributions to chemotherapeutic research and vaccine development.
  • To showcase progress in various communicable disease control programs funded or coordinated by WHO.
  • To provide examples of WHO's impact on global health research.

Main Methods:

  • Literature review of WHO-funded and coordinated research activities.

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  • Compilation of examples from diverse fields of infectious disease research.
  • Analysis of progress in human trials, chemotherapy studies, and control programs.

    • Main Results:

    • Significant progress in human trials for anti-sporozoite vaccines against Plasmodium falciparum malaria.
    • Advancements in chemotherapeutic studies using artemisinin and halofantrine.
    • Development of pragmatic and systemic vaccination approaches for leishmaniasis.
    • Research on chemotherapy for leishmanial infections, African leishmaniasis, and Chagas' disease.
    • Anticipated impact of ivermectin in onchocerciasis control and studies on new filaricides.
    • Progress in diarrheal diseases control programs.
    • Control strategies for taeniasis/cysticercosis, ascariasis, and hookworm via population-based chemotherapy.

    Conclusions:

    • WHO plays a pivotal role in advancing chemotherapeutic research and vaccine development globally.
    • WHO-supported initiatives demonstrate significant progress in controlling major communicable and parasitic diseases.
    • Continued investment and coordination by WHO are crucial for addressing global health challenges.