C-reactive protein-immunoglobulin complexes in two patients with macroglobulinemia

Two patients with macroglobulinemia, one with a monoclonal IgA and the other with a monoclonal IgM, are described. In connection with cytostatic treatment and infection both patients got very high CRP-concentrations as measured by laser nephelometry. These seemed to be caused by C-reactive protein immunoglobulin complex formation as determined by immunofixation.