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Influence of Pathogens and Mechanical Stimuli in Inflammation
Israr B M Ibrahim1, Ramana Pidaparti2
1School of ECAM, College of Engineering, University of Georgia, 200 D. W. Brooks Drive, Athens, GA 30602, USA. israr@uga.edu.
Bioengineering (Basel, Switzerland)
|June 28, 2019
Summary
This study models cell communication during inflammation. Different stimuli, like pathogens and mechanical stress, alter cell networks, impacting inflammation resolution and immune system resilience.
Area of Science:
- Computational Biology
- Immunology
- Systems Biology
Background:
- Inflammation involves complex cell-cell communication.
- Understanding factors influencing inflammation's time course is crucial.
- Mechanical stimuli (strain) and pathogens are key inflammation drivers.
Purpose of the Study:
- To propose a cell-cell communication model for studying inflammation dynamics.
- To analyze how strain and/or pathogens affect inflammation.
- To infer and analyze the communication network between macrophages and fibroblasts during inflammation.
Main Methods:
- An agent-based model was used to simulate inflammation.
- Macrophages and fibroblasts were modeled with cytokine signaling.
- A communication network (TE network) was inferred and analyzed.
Main Results:
- TE network characteristics can discriminate factors driving inflammation.
- Pathogen-only inflammation shows slower information exchange.
- Multiple stimuli promote information exchange, aiding inflammation resolution.
Conclusions:
- TE networks capture innate immune system dynamics and pathogen invasion history.
- Understanding these networks improves insights into system resilience.
- Cell-cell communication network analysis is key to inflammation research.
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