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[Fulminant hepatitis in Listeria septicemia]
A Tschumper1, H Streuli, S Hottinger
1Medizinische Klinik, Zieglerspital und Pathologisches Institut der Universität, Bern.
Schweizerische Medizinische Wochenschrift
|December 12, 1987
Summary
Listeria monocytogenes infection caused severe hepatitis, meningitis, and multiorgan failure in a patient. This case highlights Listeria monocytogenes as a cause of hepatitis, contributing to a small number of reported cases.
Area of Science:
- Hepatology
- Infectious Diseases
- Pathology
Background:
- Listeria monocytogenes is a facultative intracellular bacterium.
- While typically causing gastrointestinal illness or listeriosis in vulnerable populations, it can present with diverse clinical manifestations.
Observation:
- A 44-year-old male presented with acute severe icteric hepatitis.
- Blood cultures confirmed Listeria monocytogenes.
- The patient developed meningitis and succumbed to multiorgan failure.
Findings:
- Autopsy revealed nodular cirrhosis, cholestatic hepatitis, and subacute liver dystrophy.
- Granulomatous meningitis was also identified.
Implications:
- This case adds to the limited literature on hepatitis attributed to Listeria monocytogenes.
- It underscores the potential for Listeria monocytogenes to cause severe hepatic and neurological disease in immunocompetent adults.
- Further investigation into the pathogenesis of Listeria monocytogenes-induced hepatitis is warranted.