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Related Concept Videos

Regulation of Stroke Volume01:27

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
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Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
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Infection as a Stroke Trigger.

Solly Sebastian1, Laura K Stein1, Mandip S Dhamoon

  • 1From the Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.

Stroke
|June 28, 2019
PubMed
Summary
This summary is machine-generated.

Infections increase the risk of stroke, especially acute ischemic stroke. Urinary tract infections showed the strongest link to acute ischemic stroke, while respiratory infections were linked to subarachnoid hemorrhage.

Keywords:
hospitalizationinfectionprecipitating factorssubarachnoid hemorrhageurinary tract infection

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Epidemiology

Background:

  • The relationship between infection types and specific stroke subtypes remains unclear.
  • Understanding these associations is crucial for stroke prevention and management.

Purpose of the Study:

  • To investigate the association between various infections and different stroke subtypes.
  • To analyze infection exposure in different time windows preceding stroke events.

Main Methods:

  • Utilized New York State Inpatient and Emergency Department Databases (2006-2013).
  • Employed case-crossover analysis with conditional logistic regression.
  • Identified stroke subtypes (AIS, ICH, SAH) and infections using ICD-9 codes.

Main Results:

  • All infection types were linked to increased odds of acute ischemic stroke (AIS).
  • Urinary tract infections (UTI) showed the highest association with AIS (OR 5.32 within 7 days).
  • Respiratory infections were associated with subarachnoid hemorrhage (SAH) (OR 3.67 within 14 days).

Conclusions:

  • Infections are significant risk factors for acute ischemic stroke.
  • Urinary tract infections present a particularly strong association with AIS.
  • Specific infections may be linked to distinct stroke subtypes, warranting further investigation.