Development of temperature controller-integrated portable HIFU driver for thermal coagulation.

Area of Science:

• Biomedical Engineering
• Medical Physics

Background:

• Accurate temperature monitoring is crucial for effective high-intensity focused ultrasound (HIFU) therapy to control thermal coagulation.
• Achieving desired treatment outcomes in HIFU relies on precise temperature regulation.

Purpose of the Study:

• To design and evaluate a portable HIFU driver integrated with a proportional-integral-derivative (PID) temperature controller.
• To assess the feasibility of real-time temperature regulation for thermal coagulation using HIFU.

Main Methods:

• A portable HIFU driver was engineered, operating at 2 MHz with a 50 V maximum output voltage and pulse-width modulation.
• Ex vivo bovine liver tissue temperature was monitored using a K-type thermocouple during HIFU exposure.

Main Results:

• The PID-controlled HIFU driver maintained tissue temperature at 60°C during a 300-second exposure by modulating output voltage.
• Target temperature of 60°C was reached within 70 seconds, with temperature deviations under 4°C.

Conclusions:

• The developed PID controller-integrated HIFU driver is a viable portable tool for real-time tissue temperature regulation.
• This technology facilitates precise thermal coagulation through HIFU sonication.