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Updated: Jan 22, 2026

Straightforward Assay for Quantification of Social Avoidance in Drosophila melanogaster
Published on: December 13, 2014
No IL-18BP? Avoid HAV
1Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO diamond@wusm.wustl.edu.
Abstract:
Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue of JEM, Belkaya et al. (https://doi.org/10.1084/jem.20190669) identify a deletion in the IL18BP gene in a severely affected child that results in excessive natural killer cell activation and uncontrolled killing of hepatocytes.
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