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Updated: Jan 22, 2026
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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
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Adipose tissue as a key player in obstructive sleep apnoea
Silke Ryan1,2,3, Claire Arnaud4,3, Susan F Fitzpatrick1
1School of Medicine, The Conway Institute, University College Dublin, Dublin, Ireland.
Summary
Obstructive sleep apnoea (OSA) causes intermittent hypoxia (IH), leading to adipose tissue inflammation and dysfunction. This review summarizes IH effects on fat tissue, aiding personalized OSA care.
Area of Science:
- Cardiovascular Sciences
- Metabolic Diseases
- Sleep Medicine
Background:
- Obstructive sleep apnoea (OSA) is a prevalent condition linked to obesity and severe comorbidities like hypertension and metabolic dysfunction.
- The complex interplay between OSA and cardiometabolic diseases significantly impacts patient outcomes and mortality.
- Intermittent hypoxia (IH), characterized by repetitive oxygen desaturation/re-oxygenation cycles in OSA, is a key suspected driver of these complications.
Purpose of the Study:
- To comprehensively review the effects of IH on adipose tissue.
- To synthesize findings from experimental models and controlled trials concerning IH and adipose tissue.
- To identify potential pathways for improved phenotyping and personalized management of OSA.
Main Methods:
- Systematic review of experimental models investigating IH effects on adipose tissue.
- Analysis of data from controlled trials examining IH and metabolic parameters.
- Literature synthesis focusing on adipose tissue inflammation and dysfunction in the context of OSA.
Main Results:
- Growing evidence indicates that IH detrimentally affects adipose tissue, promoting inflammation and dysfunction.
- Experimental models demonstrate specific mechanisms by which IH impacts fat tissue.
- Controlled trials provide further support for the link between IH and adverse metabolic consequences.
Conclusions:
- IH is a critical mediator of cardiometabolic complications in OSA, acting partly through adipose tissue.
- Understanding IH-induced adipose tissue changes is crucial for developing targeted therapies.
- Further research into phenotyping and personalized care strategies for OSA is warranted.
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