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RNA Secondary Structure Prediction Using High-throughput SHAPE
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From observing to predicting single-cell structure and function with high-throughput/high-content microscopy.

Anatole Chessel1, Rafael E Carazo Salas2

  • 1École polytechnique, Université Paris-Saclay, 91128 Palaiseau Cedex, France.

Essays in Biochemistry
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PubMed
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Cell microscopy now predicts cell function using AI and big data. Combining cell microscopy with single-cell

Keywords:
Machine Learningcausal cell behaviourgene regulatory networksgenome-wide screeninghigh-content microscopyhigh-throughput microscopy

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Area of Science:

  • Cell biology
  • Bioinformatics
  • Computational biology

Background:

  • Cell-based microscopy has shifted from observing to predicting cellular function.
  • Advancements in computer vision, image analysis, and machine learning drive this evolution.
  • High-throughput and high-content microscopy generate valuable single-cell data.

Purpose of the Study:

  • To review developments in cell-based microscopy for predicting cell function.
  • To discuss emerging trends at the intersection of cell microscopy and single-cell 'omics.
  • To highlight the potential of integrating these fields for a deeper understanding of cellular behavior.

Main Methods:

  • Leveraging breakthroughs in computer vision and machine learning.
  • Utilizing large-scale image analysis of high-throughput and high-content microscopy data.
  • Systematic discovery and annotation of genes and regulatory pathways using single-cell information.

Main Results:

  • Enabled systematic discovery and annotation of genes and regulatory pathways.
  • Facilitated uncovering of systems-level interactions and causal links in cellular processes.
  • Advanced the clarification and prediction of causal cellular behavior and decision-making.

Conclusions:

  • Cell-based microscopy's predictive power has significantly advanced.
  • The integration of single-cell 'omics and microscopy is a key emerging trend.
  • This convergence promises unprecedented insights into cell and tissue function and behavior.