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Gene expression across mammalian organ development.

Margarida Cardoso-Moreira1,2, Jean Halbert3, Delphine Valloton3

  • 1Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany. m.moreira@zmbh.uni-heidelberg.de.

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|June 28, 2019
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Summary
This summary is machine-generated.

This study maps gene expression during mammalian organ development across seven species. It reveals how gene expression changes, selection pressures evolve, and organ development timing differs, providing a key resource for evolutionary developmental biology.

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Area of Science:

  • Developmental Biology
  • Evolutionary Biology
  • Genomics

Background:

  • Gene expression's role in mammalian organ development is poorly understood.
  • Comparative transcriptomic data across species and developmental stages is lacking.

Purpose of the Study:

  • To characterize the evolution of gene expression during mammalian organ development.
  • To provide a comprehensive resource of developmental transcriptomes for comparative analysis.

Main Methods:

  • Collected transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary, testis).
  • Analyzed data across multiple developmental time points and seven species (human, rhesus macaque, mouse, rat, rabbit, opossum, chicken).
  • Compared gene expression patterns to identify developmental stage correspondences and evolutionary differences.

Main Results:

  • Identified conserved developmental stages across species and distinct timing in gonad development.
  • Observed a decrease in gene expression breadth and purifying selection, with an increase in positive selection and new gene expression during development.
  • Found significant variation in temporal gene expression trajectories across species, with brain tissues showing stability and liver/testis showing dynamic changes.

Conclusions:

  • This study provides a valuable resource for understanding mammalian organ development and evolution.
  • Comparative transcriptomics reveals dynamic shifts in selection pressures and gene expression during development.
  • Differences in developmental timing and gene expression trajectories highlight species-specific evolutionary paths.