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Related Experiment Videos

Osteosarcoma with a clear-cell component.

C Povýsil1, Z Matĕjovský, H Zídková

  • 12nd Institute of Pathology, Faculty of General Medicine, Charles University, Praha, Czechoslovakia.

Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1988
PubMed
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Neoadjuvant Hypertermic Isolated Limb Perfusion in Treatment of Undifferentiated Spindle Cell Sarcoma of Lower Limb with Achieved Complete Pathologic Response.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2019

This study details light microscopical and ultrastructural findings in osteosarcomas with abundant clear cells. These clear cells, characterized by glycogen deposits or vacuolar degeneration, are crucial for differential diagnosis of bone tumors.

Area of Science:

  • Oncology
  • Pathology
  • Histology

Background:

  • Osteosarcomas typically exhibit a spindle cell morphology.
  • Unusual histological variants can complicate diagnosis.

Purpose of the Study:

  • To describe the light microscopical and ultrastructural features of osteosarcomas with a high proportion of clear cells.
  • To evaluate the significance of these clear cells in the differential diagnosis of bone tumors.

Main Methods:

  • Light microscopy and ultrastructural examination of three conventional osteosarcomas.
  • Histochemical analysis for glycogen deposits.
  • Immunohistochemical staining for S-100 protein.

Main Results:

  • Clear cells were found scattered or in demarcated groups within the fibroblastic tumor component.

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  • Cytoplasm revealed exaggerated glycogen deposits or vacuolar degeneration.
  • S-100 protein was notably absent in the clear cells, distinguishing them from clear-cell chondrosarcoma.

    • Conclusions:

    • The presence of clear cells significantly alters the histological pattern of conventional osteosarcomas.
    • Absence of S-100 protein is a key feature in differentiating these osteosarcomas from clear-cell chondrosarcoma.
    • These ultrastructural and histochemical findings are important for accurate bone tumor differential diagnosis.