Molecular Containers Derived from [60]Fullerene through Peroxide Chemistry
1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , China.
Accounts of Chemical Research
|June 28, 2019
Summary
Open-cage fullerenes act as molecular containers, successfully encapsulating small molecules like water, hydrogen, and oxygen. Researchers are exploring their potential in areas such as oxygen delivery for biomedical applications.
Area of Science:
- Supramolecular Chemistry
- Materials Science
- Nanotechnology
Background:
- Molecular containers isolate guest molecules, with applications in catalysis and drug delivery.
- Open-cage fullerenes, derived from fullerenes, offer unique structural properties as molecular containers.
- Previous research focused on synthesizing open-cage fullerenes and encapsulating small molecules like water.
Purpose of the Study:
- To present results on small molecule encapsulation within open-cage fullerenes.
- To explore the functional properties and potential applications of these host-guest systems.
- To investigate controlled encapsulation and release mechanisms.
Main Methods:
- Synthesis of open-cage fullerenes using fullerene-mixed peroxides.
- Quantitative encapsulation of water achieved by heating in a specific solvent mixture.
- Study of water release kinetics using blackbody infrared radiation-induced dissociation (BIRD) and theoretical calculations; release also induced by H-bonding with HF.
Main Results:
- Successful quantitative encapsulation of water, H2, HF, CO, O2, and H2O2 in various open-cage fullerenes.
- Demonstration of controlled water release using switchable stoppers and H-bonding.
- Unusual encapsulation of CO from a skeleton carbon and slow release of O2/H2O2, indicating potential as oxygen-releasing materials.
Conclusions:
- Open-cage fullerenes are effective molecular containers for a range of small molecules.
- Controlled encapsulation and release mechanisms have been developed.
- Further research will focus on optimizing synthesis and exploring applications, including oxygen delivery for photodynamic therapy.
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