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Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function
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Nanostructure Endows Neurotherapeutic Potential in Optogenetics: Current Development and Future Prospects.
Mohammed Nadim Sardoiwala1, Anup K Srivastava1, Surajit Karmakar1
1Institute of Nano Science and Technology , Habitat Centre , Phase-10, Mohali , Punjab 160062 , India.
ACS Chemical Neuroscience
|June 28, 2019
Summary
Nanotechnology enhances optogenetics for cellular control, overcoming light penetration limits. Nanomaterials offer new therapeutic potential for neurological disorders and blindness.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Neuroscience
Background:
- Optogenetics enables cellular control using light, but faces challenges with deep tissue penetration and invasiveness.
- Current methods for neuronal stimulation require direct light delivery, limiting applications.
Purpose of the Study:
- To review the application of nanotechnology in optogenetics.
- To explore how nanomaterials can overcome existing limitations in optogenetic therapies.
- To highlight the therapeutic potential of nanotech-enhanced optogenetics for various diseases.
Main Methods:
- Utilizing metal nanoparticles (AuNPs), upconversion nanocrystals (UCNCs), and quantum dots (CdSe) for targeted light emission.
- Investigating optothermal and magnetothermal properties, photoluminescence, and photostability of nanomaterials.
- Analyzing nanostructure characteristics and ion channel targeting for therapeutic applications.
Main Results:
- Nanomaterials can emit specific light upon excitation, addressing poor light penetration issues.
- Optothermal and magnetothermal properties, along with photoluminescence and photostability, are key features for therapeutic use.
- Nanomaterial-based optogenetics shows promise for treating neurodegenerative disorders, epilepsy, and blindness.
Conclusions:
- Nanotechnology offers a promising approach to enhance optogenetic therapies.
- Nanomaterials provide superior mechanical and optical characteristics for treating intractable diseases.
- This review compiles critical information on nanomaterials for advanced optogenetic therapeutics.
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