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Effect of verapamil on platelet surface ultrastructure and calcium content
M Djaldetti1, R Gilgal, P Fishman
1Department of Medicine B, Tel Aviv University Medical School, Petah-Tiqva, Israel.
Acta Haematologica
|January 1, 1988
Abstract:
The effect of verapamil on the surface ultrastructure and calcium content of human platelets was studied by scanning electron microscopy and X-ray microanalysis. The results showed that the drug prevents platelet pseudopodia formation and causes a dose-dependent inhibition of platelet calcium concentration. The significance of these findings in the explanation of the inhibitory effect of verapamil on platelet aggregation is discussed.