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Childhood Neurodevelopmental Outcome in Low Birth Weight Infants With Post-ligation Cardiac Syndrome After Ductus

Maria Carmen Bravo1, Marta Ybarra1, Rosario Madero2

  • 1Department of Neonatology, La Paz University Hospital, Madrid, Spain.

Frontiers in Physiology
|June 28, 2019
PubMed

Insights

Post-ligation cardiac syndrome (PLCS) in preterm infants undergoing patent ductus arteriosus (PDA) surgery may increase the risk of neurodevelopmental impairment. Further research is needed to confirm this association in survivors.

Area of Science:

  • Neonatalogy
  • Pediatric Cardiology
  • Developmental Pediatrics

Background:

  • Post-ligation cardiac syndrome (PLCS) is a known complication following surgical closure of patent ductus arteriosus (PDA) in preterm infants.
  • While associated with mortality, the long-term neurodevelopmental outcomes for survivors of PLCS remain understudied.

Purpose of the Study:

  • To determine the prevalence of PLCS in infants undergoing PDA ligation.
  • To investigate if PLCS is a risk factor for moderate to severe neurodevelopmental disabilities in survivors.

Main Methods:

  • Retrospective review of medical charts for infants born before 30 weeks gestation who underwent PDA ligation between 2005 and 2009.
  • Follow-up assessments of neurodevelopmental outcomes were conducted at a mean age of 5.3 years.

Main Results:

  • Twenty-six percent of the 39 preterm infants developed PLCS.
  • Neurodevelopmental impairment was observed in 75% of the PLCS group versus 37% in the no PLCS group (p=0.08).
  • Multiple regression analysis identified PLCS and low birth weight as predictors of adverse outcomes (p=0.018).

Conclusions:

  • Preterm infants with PLCS after PDA closure show a potential increased risk for long-term neurodevelopmental impairment.
  • Prospective studies with long-term follow-up are recommended to validate these findings.
Abstract

Keywords:
cardiorespiratory instabilityductus arteriosusductus ligationneurodevelopmentpreterm

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