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Updated: Jan 22, 2026
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Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks
Published on: February 10, 2023
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Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy
Yuan Liu1, Christina S Gong1, Lisen Lin1
1Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States.
Theranostics
|June 28, 2019
Summary
Researchers developed a novel MOF@NP structure for enhanced photodynamic therapy. This system uses a fluorescence switch activated by glutathione (GSH) for targeted tumor treatment and imaging.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Hybrid metal-organic framework (MOF) nanomaterials (NP@MOF) offer enhanced properties.
- MOF@NP structures with multifunctionality are underexplored.
Purpose of the Study:
- To develop a MOF@NP system for enhanced photodynamic therapy (PDT).
- To design a fluorescence switch for controlled PDT activation.
- To evaluate the in vitro and in vivo efficacy of the MOF@NP system.
Main Methods:
- In-situ growth method to create MOF@NP core-shell structures.
- Utilized porphyrinic ZrMOF nanoparticles coated with MnO2.
- Investigated fluorescence and photodynamic activity switching by MnO2 and GSH.
Main Results:
- Achieved core-shell ZrMOF@MnO2 nanoparticles with switchable fluorescence and photodynamic activity.
- MnO2 deactivated activity, while GSH reactivated it, depleting intracellular GSH.
- Demonstrated enhanced PDT efficacy in a murine tumor model.
- GSH-reduced Mn2+ enabled MRI-guided tumor therapy.
Conclusions:
- Inorganic nanomaterials significantly impact MOF properties.
- Developed a multifunctional MOF-inorganic nanomaterial complex for targeted cancer therapy.
- Provides insights for designing advanced MOF-based therapeutic agents.
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