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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Current and emerging immunotherapeutic approaches to the treatment of multiple myeloma

Dawn Swan1, Kevin Lynch2, Mark Gurney3

  • 1Clinical Research Facility, University Hospital Galway, Newcastle Road, Galway, H91 YR71, Ireland.

Therapeutic Advances in Hematology
|June 28, 2019
PubMed

Multiple myeloma (MM) has a worldwide incidence of 1-5/100,000/year. Outcomes have improved significantly in recent years following incorporation of immunomodulatory drugs and proteasome inhibitors into standard-of-care regimes. MM is profoundly immunosuppressive, enabling immune evasion, proliferation and disease progression. The role of the immune system in MM is becoming increasingly characterized and understood, and numerous therapies are under development or in routine clinical use targeting these elements of MM pathogenesis. In this review we discuss the immunosuppressive effects of MM, then the therapies targeting these defects. Specifically, we review the monoclonal and bispecific antibodies, alongside adoptive cellular therapies currently under investigation.

Keywords:
CAR T-cellantibodiesimmunotherapymyeloma

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