Related Experiment Videos
Thorotrast-induced hepatic angiosarcoma with 39 years latency. A pathologic and immunohistochemical study
Acta Pathologica Japonica
|October 1, 1987
Summary
This autopsy case reveals hepatic angiosarcoma in a patient with prior Thorotrast angiography. Thorotrast deposits were widespread, and tumor cells showed variable factor VIII-related antigen expression.
Area of Science:
- Pathology
- Oncology
- Radiology
Background:
- Reports an autopsy case of hepatic angiosarcoma in a 64-year-old male.
- The patient had undergone Thorotrast angiography 39 years prior to death.
Observation:
- Thorotrast deposits were identified in the liver, spleen, bone marrow, lymph nodes, and right elbow joint.
- The hepatic angiosarcoma was associated with distended sinusoids and hypertrophic, hyperplastic endothelial cells.
Findings:
- Immunohistochemical analysis showed limited anti-factor VIII-related antigen (anti-F VIII-RAG) staining in tumor cells and sinusoidal endothelial cells.
- Endothelial cells in portal areas exhibited distinct positive staining for anti-F VIII-RAG.
Implications:
- Suggests that factor VIII-related antigen production by tumor cells may depend on cellular dedifferentiation.
- Highlights the potential heterogeneity of endothelial cells in the context of Thorotrast-induced angiosarcoma.