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Sugar, Spice, and Bleeding.

Zainab Shahid1, Ricci Kalayanamitra2, Maria Hanafi3

  • 1Internal Medicine, Lake Erie College of Osteopathic Medicine, Erie, USA.

Cureus
|June 28, 2019
PubMed
Summary
This summary is machine-generated.

Brodifacoum, a potent anticoagulant rodenticide, is now found in synthetic cannabinoids. A young male experienced bleeding symptoms due to brodifacoum poisoning from synthetic cannabinoid use.

Keywords:
bleedingbrodifacoumcoagulopathylong-acting anticoagulant rodenticidesuperwarfarinsynthetic cannabinoid

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Area of Science:

  • Toxicology
  • Pharmacology
  • Internal Medicine

Background:

  • Brodifacoum (BDF) is a long-acting anticoagulant rodenticide (LAAR) functioning as a vitamin K antagonist.
  • BDF irreversibly inhibits vitamin K epoxide reductase, impairing clotting factor synthesis (Factors II, VII, IX, X).

Observation:

  • A young male presented with hematuria and epistaxis.
  • The patient had a history of synthetic cannabinoid use.

Findings:

  • The patient was diagnosed with brodifacoum (BDF) poisoning.
  • BDF was identified as an additive in the synthetic cannabinoids used by the patient.

Implications:

  • This case highlights a novel route of BDF exposure through synthetic cannabinoids.
  • Clinicians should consider BDF poisoning in patients with bleeding complications and synthetic cannabinoid use history.
  • This finding necessitates enhanced monitoring and regulation of synthetic cannabinoid formulations.