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Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

Qingmei Ye1, Kai Liu1, Qun Shen1

  • 1Hainan General Hospital, Haikou, China.

Frontiers in Oncology
|June 28, 2019
PubMed

Insights

Flavonoids, natural compounds found in plants, can overcome multidrug resistance (MDR) in cancer. These compounds act as multi-functional agents, targeting key factors contributing to MDR without specific protein regulation.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Multidrug resistance (MDR) in cancer presents a significant clinical treatment challenge.
  • Existing MDR reversal agents often fail due to adverse effects.
  • Natural products, particularly flavonoids, show promise in overcoming MDR.

Purpose of the Study:

  • To review and discuss the mechanisms by which flavonoids and iso-flavonoids overcome MDR.
  • To highlight the multi-functional nature of these compounds in combating cancer resistance.

Main Methods:

  • Literature review of research on flavonoids and cancer MDR.
  • Analysis of structural classifications of flavonoids (flavonoids, iso-flavonoids, neo-flavonoids).
  • Discussion of bioactivities and underlying mechanisms of action.

Main Results:

  • Flavonoids and iso-flavonoids demonstrate the ability to kill or re-sensitize resistant cancer cells.
  • These compounds exhibit multi-functional activity rather than specific target protein regulation.
  • Key factors contributing to MDR are negatively regulated by flavonoids.

Conclusions:

  • Flavonoids represent a promising class of natural products for overcoming cancer MDR.
  • Their multi-functional mechanism offers an alternative approach to MDR reversal.
  • Further research into flavonoids could lead to improved cancer therapies.
Keywords:
cancerdrug discoveryflavonoidsmultidrug resistancenatural productsovercome

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