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Updated: Jan 22, 2026

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
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A heparin-modified thermoresponsive surface with heparin-binding epidermal growth factor-like growth factor for

Yoshinori Arisaka1, Jun Kobayashi1, Kazuo Ohashi1

  • 1Institute of Advanced Biomedical Engineering and Science and Global Center of Excellence (COE) Program, Tokyo Women's Medical University (TWIns), 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.

Regenerative Therapy
|June 28, 2019
PubMed

Keywords:
Alb, albuminCIPAAm, 2-carboxyisopropylacrylamideDMEM, Dulbecco's modified Eagle's mediumECM, extracellular matrixEDC, 1-ethyl-3-(3-dimetylaminopropyl)-carbodiimide hydrochlorideEDTA, trypsin/ethylenediaminetetraacetic acidEGF, epidermal growth factorELISA, enzyme-linked immunosorbent assayF7, coagulation factor VIIF9, coagulation factor IXFBS, fetal bovine serumHB-EGF, heparin-binding EGF-like growth factorHB-EGFX/heparin-IC, HB-EGF-bound heparin-ICHeparinHeparin-binding EGF-like growth factorHepatocyte sheetHnf4α, hepatocyte nuclear factor 4 alphaIC, poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide) on TCPSIPAAm, N-isopropylacrylamideMES, morpholinoethanesulfonic acid monohydrateNHS, N-hydroxysuccinimidePBS, Dulbecco's phosphate buffered salinePIPAAm, poly(N-isopropylacrylamide) on TCPSPIPAAm + HB-EGFY, PIPAAm with soluble HB-EGFPoly(N-isopropylacrylamide)RT-PCR, reverse transcription polymerase chain reactionTCPS, tissue culture polystyrene disheThermoresponsive cell culture surfacebFGF, basic fibroblast growth factorheparin-IC, heparin-modified IC

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