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Ranking Oxidant Sensitiveness: A Guide for Synthetic Utility
Madeleine A Dallaston1, Christian J Bettencourt1, Sharon Chow1
1School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072, Australia.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 28, 2019
Summary
Researchers assessed the safety of chemical oxidants, including perruthenates. Methyltriphenylphosphonium perruthenate and related compounds were found to be highly sensitive, while Oxone and manganese dioxide were deemed safer options.
Area of Science:
- Chemical synthesis
- Reaction hazard assessment
- Materials science
Background:
- Chemical oxidants are crucial in synthesis but can pose significant hazards.
- Newly developed perruthenates require thorough safety evaluation.
- Understanding reagent sensitivity is key to preventing accidents.
Purpose of the Study:
- To evaluate the sensitivity and potential hazards of common chemical oxidants.
- To compare the safety profiles of perruthenates with other oxidizing agents.
- To establish a reliable ranking of oxidant sensitivity.
Main Methods:
- Utilized sealed cell differential scanning calorimetry (scDSC) for thermal analysis.
- Performed Yoshida correlations to analyze thermal data.
- Conducted impact sensitiveness and electrostatic discharge (ESD) experiments.
- Ranked reagents based on combined sensitivity data.
Main Results:
- Methyltriphenylphosphonium perruthenate (MTP3), isoamyltriphenylphosphonium perruthenate (ATP3), and tetraphenylphosphonium perruthenate (TP3) were identified as the most sensitive oxidants.
- 2-Iodoxybenzoic acid (IBX) and benzoyl peroxide (BPO) exhibited moderate sensitivity.
- Oxone, manganese dioxide (MnO2), and N-bromosuccinimide (NBS) were found to be the least sensitive and most benign.
Conclusions:
- Perruthenate compounds, particularly MTP3, ATP3, and TP3, present significant safety concerns due to high sensitivity.
- A clear sensitivity ranking of common oxidants was established, aiding in safer chemical process design.
- The study highlights the importance of rigorous hazard assessment for novel synthetic reagents.
Keywords:
differential scanning calorimetryelectrostatic discharge experimentsimpact sensitivenessoxidantMore Related Videos
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