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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Marginal zone lymphomas: second most common lymphomas in older patients
Dominique Bron1, Nathalie Meuleman,
1Department of Hematology, Institut Jules Bordet (ULB), Brussels, Belgium.
Current Opinion in Oncology
|June 28, 2019
Summary
Optimal treatment for older adults with indolent lymphomas requires a geriatric assessment. Tailored strategies for marginal zone lymphoma subtypes improve outcomes while managing comorbidities and toxicity.
Area of Science:
- Hematology
- Oncology
- Geriatrics
Background:
- Treating older adults with indolent lymphomas presents unique challenges due to comorbidities and potential toxicities.
- A comprehensive geriatric assessment is crucial for tailoring treatment plans in this population.
Purpose of the Study:
- To provide specific recommendations for the treatment and supportive care of older patients with different subtypes of marginal zone lymphomas.
- To address the complexities of managing potentially curable and incurable conditions concurrently in elderly lymphoma patients.
Main Methods:
- Literature review of current therapeutic approaches for indolent lymphomas in older adults.
- Analysis of geriatric assessment components including life expectancy, prognostic factors, functional status, and quality of life.
Main Results:
- Geriatric assessment enables the adaptation of standard treatments for older marginal zone lymphoma patients.
- Extranodal MALT lymphoma: pathogen eradication is key; advanced stages benefit from observation or anti-CD20 therapy.
- Nodal and Splenic MZL: management strategies align with follicular lymphomas, with specific considerations for hepatitis and symptomatic treatment.
Conclusions:
- Personalized treatment strategies based on geriatric assessment are vital for older patients with indolent lymphomas.
- Specific protocols for extranodal, nodal, and splenic marginal zone lymphomas optimize care for elderly individuals.
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