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Linear IgA Disease of the Gingiva Following Nivolumab Therapy

Sushma Jonna1, Mirdza Neiders2,3, Suresh Lakshmanan2,3

  • 1Department of Medicine, Lombardi Comprehensive Cancer Center.

Journal of Immunotherapy (Hagerstown, Md. : 1997)
|June 28, 2019
PubMed

Immunotherapy has advanced the treatment of solid organ malignancies. Although generally well tolerated, treatment with immune checkpoint inhibitors can be complicated by immune-related adverse events, some of which are relatively uncommon. We report the first case of gingival linear immunoglobulin A disease related to treatment with an antiprogrammed cell death protein 1 antibody. A 73-year-old male with advanced non-small cell lung cancer achieved a durable response to nivolumab monotherapy. After 1 year of treatment, he developed gingival swelling and pain. Biopsy revealed linear immunoglobulin A disease of the gingiva which was effectively treated with systemic steroids. Ongoing vigilance for immune-mediated toxicity is paramount during and after treatment with immune checkpoint inhibitors.

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